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TOPIC: Data on Hypertrophic Scarring presented at ABA

Data on Hypertrophic Scarring presented at ABA 05 May 2016 07:22 #6907

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Cytori Reports Preliminary Preclinical Data Supporting Use of Cytori Cell Therapy™ for Both the Prevention and Treatment of Hypertrophic Scars
May 05, 2016

Presented at 2016 American Burn Association Meeting
SAN DIEGO--(BUSINESS WIRE)-- Cytori Therapeutics, Inc. (NASDAQ: CYTX) today presented preclinical data at the Annual Meeting of the American Burn Association (ABA) in Las Vegas showing the potential of Cytori’s DCCT-10 cell therapy for hypertrophic scarring (HTS), a common consequence of burn injury.
In this research Cytori scientists developed and applied a preclinical model of HTS in two treatment studies. In the first, DCCT-10 was applied to deep partial thickness skin wounds immediately following injury. Wounds were then followed for six months to allow for the development of HTS. Results demonstrate that delivery of DCCT-10 immediately after injury led to a 60% increase in the number of anchoring structures called ‘rete ridges’ or ‘rete pegs’ within the skin (p<0.001) of treated wounds compared to the control. Rete ridges, which help to anchor the epidermis to the dermis, are absent or substantially reduced in scar tissue which is one reason that scar epidermis is often more fragile than that of normal skin. The six month data also showed a 15% decrease in skin hardness in DCCT-10-treated wounds (p=0.067). The second study, which is still ongoing, used the same model to assess use of DCCT-10 delivered six months after deep partial thickness injury in which a hypertrophic scar had already formed. Preliminary data from this study presented today show a 20-40% decrease in skin hardness at 1 and 2 months post-treatment.
While DDC-10 treatment appeared to modulate skin pliability and hardness in both studies, no effect was observed on scar pigmentation or erythema.
“These data suggest the potential for DCCT-10 therapy to mitigate scarring following deep partial thickness skin injury,” said Dr. Marc Hedrick, President and CEO of Cytori. “When combined with earlier work on the use of DCCT-10 following thermal burn injury, these findings suggest a potentially broad utility for this product in burn and wound clinics. We are encouraged by this research and look forward to completing these studies and, in a continuation of our work with BARDA, initiating a clinical trial of DCCT-10 therapy in burn patients within the next year.”
Presentations Details:
Abstract #268
Title: Non-Invasive Objective Characterization of Hypertrophic Scarring in the Female Red Duroc Porcine Model
Presenter: Philippe Foubert
Poster: P-033. Wounds – Translational II


Abstract Link : Abstract presented at ABA Meeting in Vegas

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Data on Hypertrophic Scarring presented at ABA 05 May 2016 08:05 #6909

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I see 60% written in a positive context.

Now let's translate this into BARDA dollars

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Data on Hypertrophic Scarring presented at ABA 05 May 2016 08:14 #6910

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This pre-clinical work was done in pigs but I find it odd, unless I'm missing it, that the words "pig" or "porcine model" weren't mentioned in the release.

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Data on Hypertrophic Scarring presented at ABA 05 May 2016 08:47 #6911

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WST "Title: Non-Invasive Objective Characterization of Hypertrophic Scarring in the Female Red Duroc Porcine Model"

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Data on Hypertrophic Scarring presented at ABA 05 May 2016 09:57 #6912

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I was referring to the article but you are correct it is in the title. Thanks.

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