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TOPIC: Korean study on SUI & Foubert paper

Korean study on SUI & Foubert paper 18 Jul 2016 02:45 #7423

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I decided last week to complete the set up of my News site- cell-therapy.info first, since it helps when one "is in" with the tech. Plenty of issues crop up with RSS feeds and their successful publication, so I will bring it to a stage where it has enough information and simply add on when I have spare time or "meet" something interesting during my web-travels, which I should add.

Anyway- yesterday I added a real nice PubMed query on the site- latest 10 FREE publications meeting the criteria -Adipose+Derived+Regenerative+Cells and interesting stuff came out- cell-therapy.info Query

A Korean SUI study- well well- in the land of main competition Celution as proponents also... very very interesting :grin: :grin:

PURPOSE:
We report our initial experience with transurethral injection of autologous adipose-derived regenerative cells (ADRCs) for the treatment of urinary incontinence after radical prostatectomy.
MATERIALS AND METHODS:
After providing written informed consent, six men with persistent urinary incontinence after radical prostatectomy were enrolled in the study. Under general anesthesia, about 50 mL of adipose tissue was obtained from the patients by liposuction. ADRCs were obtained by separation with centrifugation using the Celution cell-processing device. A mixture of ADRCs and adipose tissue were transurethrally injected into the submucosal space of the membranous urethra. Functional and anatomical improvement was assessed using a 24-h pad test, validated patient questionnaire, urethral pressure profile, and magnetic resonance imaging (MRI) during 12-week follow-up.
RESULTS:
Urine leakage volume was improved with time in all patients in the 24-h pad test, with the exemption of temporal deterioration at the first 2 weeks post-injection in 2 patients. Subjective symptoms and quality of life assessed on the basis of questionnaire results showed similar improvement. The mean maximum urethral closing pressure increased from 44.0 to 63.5 cm H₂O at 12 weeks after injection. MRI showed an increase in functional urethral length (from 6.1 to 8.3 mm) between the lower rim of the pubic bone and the bladder neck. Adverse events, such as pelvic pain, inflammation, or de novo urgency, were not observed in any case during follow-up.
CONCLUSION:
This study demonstrated that transurethral injection of autologous ADRCs can be a safe and effective treatment modality for postprostatectomy incontinence.



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File Name: 2016-KoreanSUIStudy.pdf
File Size: 1,079 KB


and as second find the paper from Foubert/Fraser et al what delivery method is preferred with wound healing - IV or spray.
The answer is: both work equally well. :cool:

File Attachment:

File Name: 2016-Foubert-WoundHealingDeliveryMethods.pdf
File Size: 777 KB
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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:
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