Welcome, Guest
Username: Password: Remember me
Cytori´s Platform applications
  • Page:
  • 1

TOPIC: Publication of Preclinical on Radiation and Burn

Publication of Preclinical on Radiation and Burn 24 Oct 2016 06:25 #7811

  • fas
  • fas's Avatar Topic Author
  • Offline
  • Moderator
  • Moderator
  • May the fat be with you
  • Posts: 3337
  • Thank you received: 1115
Oct 24, 2016
SAN DIEGO--(BUSINESS WIRE)-- Cytori Therapeutics, Inc. (NASDAQ: CYTX) announced today the publication of preclinical safety and efficacy study data using Cytori Cell Therapy™ for combined radiation and thermal injury. This preliminary study was performed with support from the Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services.
The paper, entitled “Development of a Combined Radiation and Full Thickness Burn Injury Minipig Model to Study the Effects of Uncultured Adipose-Derived Regenerative Cell Therapy in Wound Healing,” was published in the International Journal of Radiation Biology and is now available online.
The paper reports that injection of Cytori Cell Therapy by either local or intravenous administration led to improvement of healing of full thickness burns that were compromised by concomitant exposure to sub-lethal, marrow-damaging total body irradiation. Treated wounds exhibited 3.5-fold greater re-epithelialization at two weeks post-treatment (relative to control), increase in blood vessel density by an average of 67%, and an increase in matrix (collagen) deposition of 30%. Similar results were observed when the Therapy was injected directly into the wound or by intravenous administration. Local and intravenous Therapy delivery were well tolerated and no serious side effects related to body weight, loss of appetite, infection, activity, or complete blood counts was observed over the course of the study.
“These preclinical data support the clinical rationale for the investigational use of topical or intravenous administration of Cytori Cell Therapy in burn patients,” said Dr. John Fraser, Cytori’s Chief Scientist. “We are leveraging this data in a forthcoming U.S. FDA investigational device exemption (IDE) application for the RELIEF Phase I clinical trial to assess the safety and feasibility of the intravenously administered Cytori Cell Therapy as a novel thermal burn countermeasure.”
The current healthcare system is ill-prepared for large numbers of patients requiring simultaneous treatment. Current standard of care consists of dressings, skin grafts, and skin substitutes. Despite these treatments, patients with severe burns commonly suffer from prolonged pain, aggressive scarring, skin contracture, and reduced range of motion. Autologous Cell Therapies such as those offered by Cytori have the potential to improve the quality and rate of wound healing and reduce scarring and also can be deployed in a cost-effective manner, even in mass casualty situations.
In a mass casualty event, the Government Accountability Office estimates that as many as 10,000 patients could require thermal burn care. The limited number of specialist surgeons and burn centers in the U.S. creates a public health need for a burn wound therapy that can be quickly and broadly applied by non-specialist medical personnel following such an event. Therefore, the Cytori Cell Therapy approach represents a novel potential medical countermeasure not only to address these challenges but also to promote wound healing and tissue repair and help improve casualty care.

Please Log in or Create an account to join the conversation.

Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Publication of Preclinical on Radiation and Burn 24 Oct 2016 06:28 #7812

  • fas
  • fas's Avatar Topic Author
  • Offline
  • Moderator
  • Moderator
  • May the fat be with you
  • Posts: 3337
  • Thank you received: 1115
The paper cost 48 $ for 48 hours access :grin:

So only the abstract:

Abstract Title: Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing
Authors: Philippe Foubert, Melanie Doyle-Eisele, Andreina Gonzalez, Felipe Berard, Waylon Weber, Diana Zafra, Zeni Alfonso, Sherry Zhao, Mayer Tenenhaus & John K. Fraser
Pages 1-11 | Received 08 Feb 2016, Accepted 20 Sep 2016, Accepted author version posted online: 03 Oct 2016, Published online: 21 Oct 2016

Purpose: To develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model.

Methods: Göttingen minipigs were subjected to a 1.2 Gy total body irradiation by exposure to a 6 MV X-ray linear accelerator followed by ∼10 cm2 full thickness burns (pre-heated brass block with calibrated spring). Three days after injury, wounds were excised to the underlying fascia and each animal was randomized to receive treatment with autologous adipose-derived regenerative cells (ADRC) delivered by local or intravenous injection, or vehicle control. Blood counts were used to assess radiation-induced marrow suppression. All animals were followed using digital imaging to assess wound healing. Full-thickness biopsies were obtained at 7, 14, 21 and 30 days’ post-treatment.

Results: Compared to animals receiving burn injury alone, significant transient neutropenia and thrombocytopenia were observed in irradiated subjects with average neutrophil nadir of 0.79 × 103/μl (day 15) and platelet nadir of 60 × 103/μl (day 12). Wound closure through a combination of contraction and epithelialization from the wound edges occurred over a period of approximately 28 days’ post excision and treatment. Re-epithelialization was accelerated in wounds treated with ADRC (mean 3.5-fold increase at 2 weeks post-treatment relative to control). This acceleration was accompanied by an average 67% increase in blood vessel density and 30% increase in matrix (collagen) deposition. Similar results were observed when ADRC were injected either directly into the wound or by intravenous administration.

Conclusions: Although preliminary, this study provides a reproducible minipig model of thermal burn injury complicated by myelosuppressive total body irradiation that utilizes standardized procedures to evaluate novel countermeasures for potential use following attack by an improvised nuclear device.

Please Log in or Create an account to join the conversation.

Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Publication of Preclinical on Radiation and Burn 24 Oct 2016 06:54 #7813

  • rodney.strongg
  • rodney.strongg's Avatar
  • Offline
  • Platinum Boarder
  • Platinum Boarder
  • Posts: 1333
  • Thank you received: 19
Fas, how could this not turn into a huge business someday? We just need a cash partnership of some sort by mid-2017 and hope for the promised breakeven in 2018!

Please Log in or Create an account to join the conversation.

Publication of Preclinical on Radiation and Burn 24 Oct 2016 11:58 #7817

  • myownhedgefund
  • myownhedgefund's Avatar
  • Offline
  • Platinum Boarder
  • Platinum Boarder
  • Posts: 2825
  • Thank you received: 202
The 3 words I find important:

>>> (relative to control), <<<

Please Log in or Create an account to join the conversation.

  • Page:
  • 1
Time to create page: 0.087 seconds

Copyright Information

Copyright Fas Kuiters © 2016 young-foxes.com. All Rights Reserved.
This page is made with Joomla CMS and its various templates designed by Fas Kuiters with the excellent Themler tool.

 

 

Shared Spreadsheet Links

DOV´s Revised Projections for the Periods 2017 until 2020

Shareble link : HERE

Fas Kuiters Websites