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TOPIC: Stem cell treatment in HIV

Stem cell treatment in HIV 03 Jul 2013 13:16 #594

  • myownhedgefund
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This one is a bit strange they way it is written and very very early of course but I posted mainly due to the end of the article where they mention cost being a factor and we know Cytori is the low cost option. Note....not that the Cytori process would work here.
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Jul 3, 7:35 AM EDT


2 stem cell patients stop HIV drugs, no virus seen

By EILEEN NG
Associated Press











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KUALA LUMPUR, Malaysia (AP) -- Two HIV-positive patients in the United States who underwent bone marrow transplants for cancer have stopped anti-retroviral therapy and still show no detectable sign of the HIV virus, researchers said Wednesday.

The Harvard University researchers stressed it was too early to say the men have been cured, but said it was an encouraging sign that the virus hasn't rebounded in their blood months after drug treatment ended.

The first person reported to be cured of HIV, American Timothy Ray Brown, underwent a stem cell transplant in 2007 to treat his leukemia. He was reported by his German doctors to have been cured of HIV two years later.

Brown's doctors used a donor who had a rare genetic mutation that provides resistance against HIV. So far, no one has observed similar results using ordinary donor cells such as those given to the two patients by the Harvard University researchers.

The researchers, Timothy Henrich and Daniel Kuritzkes of the Harvard-affiliated Brigham and Women's Hospital in Boston, announced last year that blood samples taken from the men - who both had blood cancers - showed no traces of the HIV virus eight months after they received bone marrow transplants to replace cancerous blood cells with healthy donor cells. The men were still on anti-HIV drugs at the time.

The men have both since stopped anti-retroviral therapy - one 15 weeks ago and the other seven weeks ago - and show no signs of the virus, Henrich told an international AIDS conference in Malaysia on Wednesday.

"They are doing very well," Henrich said. "While these results are exciting, they do not yet indicate that the men have been cured. Only time will tell."

The HIV virus may be hiding in other organs such as the liver, spleen or brain and could return months later, he warned.

Further testing of the men's cells, plasma and tissue for at least a year will help give a clearer picture on the full impact of the transplant on HIV persistence, he said.

Kuritzkes said the patients will be put back on the drugs if there is a viral rebound.

A rebound will show that other sites are important reservoirs of infectious virus and new approaches to measuring these reservoirs will be needed in developing a cure, Henrich said.

"These findings clearly provide important new information that might well alter the current thinking about HIV and gene therapy," Kevin Robert Frost, chief executive of The Foundation of AIDS Research, said in a statement. "While stem cell transplantation is not a viable option for people with HIV on a broad scale because of its costs and complexity, these new cases could lead us to new approaches to treating, and ultimately even eradicating, HIV

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Stem cell treatment in HIV 04 Jul 2013 10:33 #601

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This is interesting. With Brown it was thought that the donor cells had a genetic mutation, which both cured has cancer and has HIV.

So a fluke - so to speak.

SC transplants as a procedure also entail that your own bone marrow, which is the source of a blood cancer is completely "destroyed" with radiation and chemo-therapy, which the transplant than kind of replaces.

That is quite hefty and not without danger. So not a cure for most HIV patients if you like- but might be a clue for digging further into.

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Stem cell treatment in HIV 04 Jul 2013 15:39 #602

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The method of destroying the patient's immune system and then rebooting it using stem cells is a valid way of treating a large number of autoimmune diseases. As we all know it has been used to treat blood cancers for years, very effectively, but there is a nonnegligible risk involved.

Scleroderma is an interesting case where this approach is used.

www.heraldsun.com.au/news/victoria/woman-gets-her-life-back-after-stem-cell-transplant-frees-her-from-effects-of-disease/story-fni0fit3-1226674478839

Interesting to note that this approach is alreay being used by Burt at Northwestern to treat many patients in a variety of indications.

www.stemcellresearchfacts.org/dr-richard-burt/

I am very hopefull that the Celution trial in France to treat systemic scleroderma may well prove to be an effective AND more benign treatment against this very serious disease. Hopefully we will get some insight at the AGM of whether this indication will progress to a bigger trial as was indicated at the 1st quarter conference call. :winky:

Burt can undertake practice of medicine as it is BM based ................ but easily accessible fat isn't BM based so we can't............. this will change the moment an EU authority gives us CE approval for scleroderma (along with the data). That could be a big wake up call to the market. :woohoo:
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