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TOPIC: Adipose stem cell trials for stroke coming?

Adipose stem cell trials for stroke coming? 07 Feb 2013 12:06 #115

  • joeycav11
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Stem Cell Therapy Helps Stroke Victims Recover in Two Weeks

By Hannah Osborne: Subscribe to Hannah's RSS feed





The rats completely recovered from a stroke within two weeks with stem cell therapy (Wiki Commons)

Stem cell therapy administered shortly after a stroke could significantly increase the sufferer's chance of a complete recovery.


When administered to rats within 30 minutes of suffering a stroke, the rodents made a full recovery within two weeks, a study showed.

The research, published in BioMed Central's open access journal Stem Cell Research & Therapy, found that stem cells from the bone marrow of fat can improve the recovery of rats following a stroke.

Researchers at La Paz University Hospital found that treatment improved the amount of brain and nerve repair, as well as the animal's ability to complete tasks.

Rats were treated intravenously with stem cells half an hour after a stroke. In humans, such rapid response is known to dramatically improve the outcome of victims.

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The researchers found improvements in the stem cell group within 24 hours of the treatment, compared to the control group.

The FAST response advertising campaign has aimed to increase awareness of symptoms. Facial and arm weakness and speech problems suggest it is time to call emergency services.

Human trials

A delay in treatment can result in death or long-term disabilities. A stroke occurs when the blood supply to part of the brain is cut off.

Within two weeks the rats treated with stem cells had near-normal scores in tests, even though the stem cells did not seem to migrate to the damaged area of the brain. They also had higher levels of biomarkers implicated in brain repair.

Stem cells from both bone marrow and fat (adipose) helped treat rats, giving strong implications for human testing. Study author Exuperio Díez-Tejedor, from La Paz University Hospital, said: "Improved recovery was seen regardless of origin of the stem cells, which may increase the usefulness of this treatment in human trials.

"Adipose-derived cells in particular are abundant and easy to collect without invasive surgery."

BBC presenter Andrew Marr recently suffered from a stroke at the age of 53. Fellow presenter Jeremy Vine recently spoke about his recovery, saying: "He's on the mend and he does send a huge thank you to friends and viewers who've bombarded him with goodwill messages.

"He says that's been truly wonderful, he's really looking forward to returning to work in due course and resuming duties on a Sunday morning."

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Adipose stem cell trials for stroke coming? 07 Feb 2013 13:01 #117

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Interesting Joey...but 30 minutes post stroke ? Talk about a almost impossible segment of treatable population even assuming off the shelf stem cells.
I am sure a trial with wider time allowances has/is/will be done but I am curious why this researcher chose such a strict and very limited time period.

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Adipose stem cell trials for stroke coming? 07 Feb 2013 13:17 #118

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You would think that with the ease of the treatment and the fact that the cells are given intrevenously that many people with stroke impairment would love to give this a try.
I would like to see a couple of trials one where cells are given within an hour and one within a month or so.
This should be paid for by government given the burden that strokes have on soceity.

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Adipose stem cell trials for stroke coming? 07 Feb 2013 13:27 #120

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IMHO...1 month equals cell death.
Speed is important...I just question the 30 minute rational.

Lots and lots of work to be done,,,it is reimbursements that are elusive. Its going to be what 2 years for breast reimbursement in the UK ??????????????????????????????????? This assuming it come by year end. We shall see if Japan is any faster with managements call for later this year.

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Adipose stem cell trials for stroke coming? 07 Feb 2013 13:47 #121

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You know what?

I recall 100% sure that I found a clinical trial on humans in the US a while back- at some reasonably well-known university hospital.
Stroke patients with ADRCs.
I just cannot find the link anymore in the complete mess that my computer is with hundreds of links as book-marks and my files with scientific papers sorted hap hazardly all across my hard disk.

I need a secretary to assist me, but cannot afford one.

Would Chris give me one as a birthday present maybe? :happy:
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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Adipose stem cell trials for stroke coming? 07 Feb 2013 14:05 #122

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Just while it crosses my mind and the topic is stroke.

I think its reasonable to assume that stroke would also be covered by the "vascular" tool claim forthcoming on Celution- whatever exactly that Tool claim implies. At least ischemic stroke.
And not to forget - the research cooperation with Fraunhofer in Germany on stroke is also still ongoing- at least it was last time I asked- that was in the summer of 2012 or there about.

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:
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