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Adult Stem Cell News and Developments other than Cytori
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TOPIC: Auto re-programmed T-cells virtually cure leukemia

Auto re-programmed T-cells virtually cure leukemia 21 Oct 2014 07:49 #2489

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This is pretty amazing stuff. :winky:

The process is similar as the denditric cells of Dendreon and other Companies, i.e. Autologous , cultured and some re-programming done, but here the source are T-cells, which are mainly often the cells that makes mistakes and often attack cells of our immune system by mistake, thinking they are intruders into our system.

Full article: Penn edu Publication

CTL019 manufacturing begins with a patient’s own T cells, which are collected via an apheresis process similar to blood donation, then reprogrammed in Penn’s Clinical Cell and Vaccine Production Facility with a gene transfer technique that teaches the T cells to target and kill tumor cells. The engineered cells contain an antibody-like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia. The modified “hunter” cells are then infused back into the patient's body, where they both multiply and attack the cancer cells. A signaling domain built into the CAR promotes rapid multiplication of the “hunter” cells, building an army of tumor-killing cells that tests reveal can grow to more than 10,000 new cells for each single engineered cell patients receive.


This is an area BIG Pharma is really keen on - re-fortifying the immune system with patentable products either small molecule or anti-body drugs, but finds very little useful stuff. Re-programmed cells must be the solution there.

The article intro:

PHILADELPHIA – Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania. The results are published this week in The New England Journal of Medicine.
The new data, which builds on preliminary findings presented at the American Society of Hematology’s annual meeting in December 2013, include results from the first 25 children and young adults (ages 5 to 22) treated at the Children’s Hospital of Philadelphia and first five adults (ages 26 to 60) treated at the Hospital of the University of Pennsylvania. Twenty-seven of the 30 patients in the studies achieved a complete remission after receiving an infusion of these engineered “hunter” cells, and 78 percent of the patients were alive six months after treatment.

“The patients who participated in these trials had relapsed as many as four times, including 60 percent whose cancers came back even after stem cell transplants. Their cancers were so aggressive they had no treatment options left,” said the study’s senior author, Stephan Grupp, MD, PhD, the Yetta Deitch Novotny Professor of Pediatrics in the Perelman School of Medicine and director of Translational Research in the Center for Childhood Cancer Research at the Children's Hospital of Philadelphia. “The durable responses we have observed with CTL019 therapy are unprecedented.”


Penn has an association with Novartis... :winky: :cool:
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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:
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